• <ins id="pjuwb"></ins>
    <blockquote id="pjuwb"><pre id="pjuwb"></pre></blockquote>
    <noscript id="pjuwb"></noscript>
          <sup id="pjuwb"><pre id="pjuwb"></pre></sup>
            <dd id="pjuwb"></dd>
            <abbr id="pjuwb"></abbr>
            隨筆 - 87  文章 - 279  trackbacks - 0
            <2025年7月>
            293012345
            6789101112
            13141516171819
            20212223242526
            272829303112
            3456789

            潛心看書研究!

            常用鏈接

            留言簿(19)

            隨筆分類(81)

            文章分類(89)

            相冊

            ACM OJ

            My friends

            搜索

            •  

            積分與排名

            • 積分 - 217940
            • 排名 - 117

            最新評論

            閱讀排行榜

            評論排行榜

            Human Gene Functions
            Time Limit:1000MS? Memory Limit:10000K
            Total Submit:866 Accepted:507

            Description
            It is well known that a human gene can be considered as a sequence, consisting of four nucleotides, which are simply denoted by four letters, A, C, G, and T. Biologists have been interested in identifying human genes and determining their functions, because these can be used to diagnose human diseases and to design new drugs for them.

            A human gene can be identified through a series of time-consuming biological experiments, often with the help of computer programs. Once a sequence of a gene is obtained, the next job is to determine its function.
            One of the methods for biologists to use in determining the function of a new gene sequence that they have just identified is to search a database with the new gene as a query. The database to be searched stores many gene sequences and their functions – many researchers have been submitting their genes and functions to the database and the database is freely accessible through the Internet.

            A database search will return a list of gene sequences from the database that are similar to the query gene.
            Biologists assume that sequence similarity often implies functional similarity. So, the function of the new gene might be one of the functions that the genes from the list have. To exactly determine which one is the right one another series of biological experiments will be needed.

            Your job is to make a program that compares two genes and determines their similarity as explained below. Your program may be used as a part of the database search if you can provide an efficient one.
            Given two genes AGTGATG and GTTAG, how similar are they? One of the methods to measure the similarity
            of two genes is called alignment. In an alignment, spaces are inserted, if necessary, in appropriate positions of
            the genes to make them equally long and score the resulting genes according to a scoring matrix.

            For example, one space is inserted into AGTGATG to result in AGTGAT-G, and three spaces are inserted into GTTAG to result in –GT--TAG. A space is denoted by a minus sign (-). The two genes are now of equal
            length. These two strings are aligned:

            AGTGAT-G
            -GT--TAG

            In this alignment, there are four matches, namely, G in the second position, T in the third, T in the sixth, and G in the eighth. Each pair of aligned characters is assigned a score according to the following scoring matrix.


            denotes that a space-space match is not allowed. The score of the alignment above is (-3)+5+5+(-2)+(-3)+5+(-3)+5=9.

            Of course, many other alignments are possible. One is shown below (a different number of spaces are inserted into different positions):

            AGTGATG
            -GTTA-G

            This alignment gives a score of (-3)+5+5+(-2)+5+(-1) +5=14. So, this one is better than the previous one. As a matter of fact, this one is optimal since no other alignment can have a higher score. So, it is said that the
            similarity of the two genes is 14.

            Input
            The input consists of T test cases. The number of test cases ) (T is given in the first line of the input file. Each test case consists of two lines: each line contains an integer, the length of a gene, followed by a gene sequence. The length of each gene sequence is at least one and does not exceed 100.

            Output
            The output should print the similarity of each test case, one per line.

            Sample Input

            2 
            7 AGTGATG 
            5 GTTAG 
            7 AGCTATT 
            9 AGCTTTAAA 

            Sample Output

            14
            21 

            Source
            Taejon 2001

            ???????#include? < iostream >
            using ? namespace ?std;

            int ?map[ 100 ][ 100 ];
            int ?initMap()
            {
            ????map[
            ' A ' ][ ' C ' ]? = ?map[ ' C ' ][ ' A ' ]? = ? - 1 ;
            ????map[
            ' A ' ][ ' G ' ]? = ?map[ ' G ' ][ ' A ' ]? = ? - 2 ;
            ????map[
            ' A ' ][ ' T ' ]? = ?map[ ' T ' ][ ' A ' ]? = ? - 1 ;
            ????map[
            ' A ' ][ ' - ' ]? = ?map[ ' - ' ][ ' A ' ]? = ? - 3 ;

            ????map[
            ' C ' ][ ' G ' ]? = ?map[ ' G ' ][ ' C ' ]? = ? - 3 ;
            ????map[
            ' C ' ][ ' T ' ]? = ?map[ ' T ' ][ ' C ' ]? = ? - 2 ;
            ????map[
            ' C ' ][ ' - ' ]? = ?map[ ' - ' ][ ' C ' ]? = ? - 4 ;

            ????map[
            ' G ' ][ ' T ' ]? = ?map[ ' T ' ][ ' G ' ]? = ? - 2 ;
            ????map[
            ' G ' ][ ' - ' ]? = ?map[ ' - ' ][ ' G ' ]? = ? - 2 ;

            ????map[
            ' T ' ][ ' - ' ]? = ?map[ ' - ' ][ ' T ' ]? = ? - 1 ;

            ????map[
            ' A ' ][ ' A ' ]? = ?map[ ' T ' ][ ' T ' ]? = ?map[ ' G ' ][ ' G ' ]? = ?map[ ' C ' ][ ' C ' ]? = ? 5 ;
            ????map[
            ' - ' ][ ' - ' ]? = ? - 128 ;
            ????
            return ? 0 ;
            }


            int ?solve()
            {
            ????
            int ?i,?j;
            ????
            char ?s1[ 105 ],?s2[ 105 ];
            ????
            int ?dp[ 105 ][ 105 ];
            ????
            int ?l1,?l2;
            ????cin?
            >> ?l1? >> ?s1? >> ?l2? >> ?s2;
            ????dp[
            0 ][ 0 ]? = ? 0 ;
            ????
            for ?(i = 1 ;?i <= l1;?i ++ )
            ????????dp[i][
            0 ]? = ?dp[i - 1 ][ 0 ]? + ?map[s1[i - 1 ]][ ' - ' ];
            ????
            for ?(i = 1 ;?i <= l2;?i ++ )
            ????????dp[
            0 ][i]? = ?dp[ 0 ][i - 1 ]? + ?map[ ' - ' ][s2[i - 1 ]];

            ????
            for ?(i = 1 ;?i <= l1;?i ++ )
            ????????
            for ?(j = 1 ;?j <= l2;?j ++ )
            ????????
            {
            ????????????dp[i][j]?
            = ?dp[i - 1 ][j - 1 ]? + ?map[s1[i - 1 ]][s2[j - 1 ]];
            ????????????
            if ?(dp[i][j]? < ?dp[i][j - 1 ]? + ?map[ ' - ' ][s2[j - 1 ]])
            ????????????????dp[i][j]?
            = ?dp[i][j - 1 ]? + ?map[ ' - ' ][s2[j - 1 ]];
            ????????????
            if ?(dp[i][j]? < ?dp[i - 1 ][j]? + ?map[s1[i - 1 ]][ ' - ' ])
            ????????????????dp[i][j]?
            = ?dp[i - 1 ][j]? + ?map[s1[i - 1 ]][ ' - ' ];
            ????????}

            ????cout?
            << ?dp[l1][l2]? << ?endl;
            ????
            return ? 0 ;
            }

            int ?main()
            {
            ????initMap();
            ????
            int ?caseTime;

            ????cin?
            >> ?caseTime;
            ????
            while ?(caseTime -- ? != ? 0 )
            ????
            {
            ????????solve();
            ????}

            ????
            return ? 0 ;
            }
            posted on 2006-08-21 15:47 閱讀(617) 評論(0)  編輯 收藏 引用 所屬分類: ACM題目
            欧美亚洲色综久久精品国产| 国产精品视频久久久| 久久久久黑人强伦姧人妻| 国产精品免费看久久久香蕉| 日本国产精品久久| 九九99精品久久久久久| 国产精品免费久久久久久久久| 热99RE久久精品这里都是精品免费| 亚洲中文久久精品无码| 大美女久久久久久j久久| 97久久国产露脸精品国产| 亚洲国产精品久久久久婷婷老年| 久久精品二区| 久久久久久亚洲精品成人| 精品久久久无码中文字幕| 亚洲va中文字幕无码久久不卡| 久久婷婷色综合一区二区| 久久久久AV综合网成人| 国产精品亚洲综合久久 | 久久无码人妻一区二区三区午夜| 大香网伊人久久综合网2020| 久久久精品人妻一区二区三区四| 精品国产一区二区三区久久蜜臀| 精品国产乱码久久久久久郑州公司 | 综合久久国产九一剧情麻豆| 久久这里只有精品久久| 亚洲AV日韩AV永久无码久久| 亚州日韩精品专区久久久| 国産精品久久久久久久| 99久久成人国产精品免费| 亚洲va久久久噜噜噜久久男同 | 久久人人青草97香蕉| 伊人色综合久久天天网| 亚洲国产精品成人久久蜜臀| 欧美午夜精品久久久久久浪潮| 国产亚洲色婷婷久久99精品91| 一本色道久久88加勒比—综合| 成人国内精品久久久久影院VR| 国产精品一久久香蕉国产线看 | 99久久久久| 亚洲人成无码久久电影网站|